Acute effects of lactate infusion on metabolism, AD biomarkers, and cognition: The LEAN study
Individuals with Alzheimer's disease (AD) can metabolize lactate as well as healthy controls. Lactate infusion might improve global cognition and processing speed. Lactate infusion results in significant decrease of AD fluid biomarkers.
Authors
- Paul J. Kueck (ORCID: https://orcid.org/0000-0002-9102-2058)
- Lance A. Johnson (ORCID: https://orcid.org/0000-0003-0134-7586)
- Jill K. Morris (ORCID: https://orcid.org/0000-0001-5911-4190)
- Chelsea N. Johnson (ORCID: https://orcid.org/0000-0003-2827-3265)
- Zachary D. Green (ORCID: https://orcid.org/0000-0003-2141-4109)
- John P. Thyfault (ORCID: https://orcid.org/0000-0001-7920-7466)
- Riley E. Kemna
- Lauren Yoksh
- Casey S. John
- Jonathan D. Mahnken
- Benjamin F. Miller (ORCID: https://orcid.org/0000-0003-1647-0122)
- Anneka Blankenship
- Hana D. Mayfield
Institutions
- University of Kentucky (US)
- University of Kansas (US)
- Oklahoma Medical Research Foundation (US)
- Oklahoma City VA Medical Center (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70984
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- National Institutes of Health