Plasma P‐tau217, GFAP, and NfL as biomarkers for Alzheimer's disease: role in disease stratification, pathological progression, and cognitive decline
Plasma p-tau217 is strongly linked to brain Aβ/tau burdens and effectively differentiates between various Aβ/tau stages. Elevated plasma levels of GFAP consistently contributed to the Aβ-induced tau progression across various Braak stages. Plasma NfL exhibits limited associations with Aβ/tau pathology, AD-specific hippocampal atrophy, and cognitive decline.
Authors
- Fengfeng Pan
- Lin Huang (ORCID: https://orcid.org/0000-0002-3753-7894)
- Fang Xie (ORCID: https://orcid.org/0000-0003-2667-281X)
- Qi Huang (ORCID: https://orcid.org/0000-0002-9425-6618)
- Qihao Guo (ORCID: https://orcid.org/0000-0001-5079-8047)
- Ying Wang (ORCID: https://orcid.org/0000-0002-7852-386X)
- Yuehua Li (ORCID: https://orcid.org/0000-0002-1504-946X)
- Yihui Guan (ORCID: https://orcid.org/0000-0002-2946-4293)
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Sixth People's Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70987
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China