From standard to stratified: Modeling NTCP and EAR to personalize daily MV‐CBCT in radiotherapy
Routine daily MV-CBCT imaging at the 10 MU protocol possesses minimal additional risk in pelvic and head & neck radiotherapy. However, among breast cancer patients, particularly those under 40 years, the 10 MU protocol significantly elevates the theoretical secondary cancer risk estimates and lung NTCP. These findings support transitioning from conventional uniform imaging approach toward personalized MV-CBCT protocols, tailored according to patient age, anatomical site, and organ radiosensitivity. A stratified imaging framework is proposed to optimize clinical outcomes, balancing treatment accuracy, and long-term patient safety.
Authors
- Nguyễn Quang Hưng (ORCID: https://orcid.org/0000-0002-9739-301X)
- Parham Alaei (ORCID: https://orcid.org/0000-0003-4847-9068)
- Dương Thanh Tài (ORCID: https://orcid.org/0000-0001-7276-8105)
- Linh T. Duong (ORCID: https://orcid.org/0000-0001-7411-1369)
- D.A. Bradley (ORCID: https://orcid.org/0000-0001-9485-5242)
- James C. L. Chow (ORCID: https://orcid.org/0000-0003-4202-4855)
- Nguyen Ngoc Anh (ORCID: https://orcid.org/0000-0002-7482-2600)
- Peter Sandwall (ORCID: https://orcid.org/0000-0001-9962-7281)
- Luong Tien Phat (ORCID: https://orcid.org/0009-0004-0963-1922)
- Tran Trung Kien
Institutions
- University of Minnesota (US)
- University Health Network (CA)
- Duy Tan University (VN)
- University of Toronto (CA)
- Princess Margaret Cancer Centre (CA)
- University of Surrey (GB)
- Trường ĐH Nguyễn Tất Thành (VN)
- Phenikaa University (VN)
- OhioHealth Mansfield Hospital (US)
- Dongfeng General Hospital (CN)
- Hanoi School Of Public Health (VN)
- Hanoi University (VN)
- Sunway University (MY)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- Journal of Applied Clinical Medical Physics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/acm2.70414
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00