Screening for Syphilis Infection During Pregnancy: US Preventive Services Task Force Reaffirmation Recommendation Statement

(Abstracted from JAMA 2025;333(22):2006-2012) The US Preventive Services Task Force (USPSTF) has reaffirmed its recommendation for universal screening for syphilis in asymptomatic, pregnant adolescent and adult women early in pregnancy or at the first available opportunity. Through a reaffirmation process that considered whether new evidence warranted a change to its 2018 recommendation, the USPSTF concluded with high certainty that the recommendation has a "substantial net benefit."