Dl‐3‐n‐Butylphthalide Promotes Cortical Angiogenesis via Akt/GSK‐3β Signaling in Ischemic Stroke Mice
In conclusion, NBP enhances recovery after ischemic stroke by promoting cortical angiogenesis and vasodilation through activation of the Akt/GSK-3β pathway. These findings highlight its therapeutic potential for delayed intervention in ischemic stroke.
Authors
- Renhao Xu (ORCID: https://orcid.org/0009-0000-8386-2869)
- Wenyan Shang
- Lina Wang (ORCID: https://orcid.org/0000-0001-5885-4496)
- Pei-Pei Zhang (ORCID: https://orcid.org/0000-0001-8161-3471)
- Lan Zhang (ORCID: https://orcid.org/0000-0002-7572-1035)
- Jian Zhang (ORCID: https://orcid.org/0000-0001-7181-6021)
- Rong Chen (ORCID: https://orcid.org/0000-0002-1794-1777)
- Shanshan Wei (ORCID: https://orcid.org/0000-0001-5473-3865)
- Jiangyong Miao (ORCID: https://orcid.org/0000-0002-7033-866X)
- Xiangjian Zhang (ORCID: https://orcid.org/0000-0003-0114-1668)
- Cong Zhang (ORCID: https://orcid.org/0009-0000-2409-2147)
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Hebei University of Chinese Medicine (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cns.70698
- Citations
- 1
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province
- Hebei Province Medical Science Research Key Project