Remimazolam‐Induced Paradoxical Reaction in a Bipolar Patient: A Case Report

This first reported case of remimazolam-induced paradoxical reaction (PR) in a bipolar disorder patient highlights that GABAergic dysfunction may heighten PR risk. Flumazenil effectively reversed the symptoms, underscoring the need for caution and preparedness when using benzodiazepines in this vulnerable population.

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Publication Details

Journal
Clinical Case Reports
Published
2025-12-01
DOI
https://doi.org/10.1002/ccr3.71624
Primary Topic
Bipolar Disorder and Treatment
Type
article
Field-Weighted Citation Impact
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article

Remimazolam‐Induced Paradoxical Reaction in a Bipolar Patient: A Case Report

Xianjie Zhang, Li Liu, Zhifu Zhao
Clinical Case Reports
Bipolar Disorder and Treatment
article

Remimazolam‐Induced Paradoxical Reaction in a Bipolar Patient: A Case Report

Xianjie Zhang, Li Liu, Zhifu Zhao
article en

Abstract

This first reported case of remimazolam-induced paradoxical reaction (PR) in a bipolar disorder patient highlights that GABAergic dysfunction may heighten PR risk. Flumazenil effectively reversed the symptoms, underscoring the need for caution and preparedness when using benzodiazepines in this vulnerable population.

Clinical Case ReportsVol. 13(12)
Deyang Stomatological Hospital (CN)
Openalex Percentile: Top 53%
Bipolar Disorder and Treatment
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Remimazolam‐Induced Paradoxical Reaction in a Bipolar Patient: A Case Report — Xianjie Zhang, Li Liu, et al. · Clinical Case Reports (2025) | TGRS Research Map | TGRS