Ketogenic Nutrition in Combination With PPARα Activation Induced Metabolic Failure and Exacerbated Muscle Weakness in Septic Mice
In septic mice, pemafibrate combined with balanced-TPN or lipid-rich TPN induced PPARα activation but did not result in ketosis nor affect muscle weakness. Pemafibrate combined with pure LCTs induced ketosis in sepsis but worsened muscle weakness, possibly explained by muscular bioenergetic failure.
Authors
- Lies Pauwels
- Sarah Derde (ORCID: https://orcid.org/0009-0005-6724-643X)
- Sarah Vander Perre
- Lies Langouche (ORCID: https://orcid.org/0000-0002-8564-6809)
- Ilse Vanhorebeek (ORCID: https://orcid.org/0000-0002-5261-5192)
- Jan Gunst (ORCID: https://orcid.org/0000-0003-2470-6393)
- Michael Paul Casaer (ORCID: https://orcid.org/0000-0002-7087-0795)
- Pieter Vermeersch (ORCID: https://orcid.org/0000-0001-7076-061X)
- Wouter Vankrunkelsven (ORCID: https://orcid.org/0000-0003-0943-043X)
- Louis Libbrecht (ORCID: https://orcid.org/0000-0002-9453-3355)
- Inge Derese
- Greet Van den Berghe (ORCID: https://orcid.org/0000-0002-5320-1362)
- Caroline Lauwers (ORCID: https://orcid.org/0000-0001-7278-2708)
Institutions
- Universitair Ziekenhuis Leuven (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jcsm.70156
- Citations
- 1
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- KU Leuven