Triglyceride levels and 12-month outcomes in patients with intracerebral hemorrhage

ObjectiveThe association between serum lipid levels and clinical outcomes following intracerebral hemorrhage remains unclear.MethodsData from consecutive patients hospitalized with intracerebral hemorrhage were prospectively collected between May 2005 and May 2018 and retrospectively analyzed. We documented the participants' baseline characteristics, clinical features, risk factors, routine laboratory test results, and outcomes at 12 months post-intracerebral hemorrhage.ResultsA total of 1450 patients with intracerebral hemorrhage were included in the final analysis. In the unadjusted model, triglyceride levels were negatively associated with the risk of poor outcomes when analyzed as a continuous variable (odds ratio, 0.83; 95% confidence interval: 0.73-0.94; P = 0.005) and a categorical variable (comparing levels above the median vs. below the median; odds ratio, 0.658; 95% confidence interval: 0.532-0.820; P < 0.001). Consistent results were observed in the fully adjusted model: triglyceride levels remained significantly negatively associated with unfavorable outcomes (continuous variable: odds ratio, 0.87; 95% confidence interval: 0.760-0.999; P = 0.049 and quartile-based categorical variable: odds ratio, 0.699; 95% confidence interval: 0.546-0.893; P = 0.005). Restricted cubic spline analysis revealed linear and nonlinear relationships between triglyceride levels and outcomes (P for linearity = 0.0005 and P for nonlinearity = 0.0075), with the most pronounced trend observed in patients aged 70-100 years.ConclusionsLow admission triglyceride levels are an independent predictor of poor 12-month outcomes in patients with intracerebral hemorrhage.