Comparing COVID-19 Variants in Children Hospitalized for Concern of Tracheostomy-associated Infection: A Multicenter Prospective Cohort Study
In this ancillary study of a larger, prospective cohort study, we sought to compare presentation and outcomes of COVID-19 infections by variant (alpha, delta, and omicron) in 103 children with tracheostomy (108 admissions) hospitalized for concern of bacterial tracheostomy-associated infection. Dexamethasone use was significantly higher with delta compared to alpha (78% vs. 40%; OR, 5.5; P = 0.04). Increased oxygen (76%-89%) and ventilatory support during hospitalization (35-67%) were noted across all variants. Death occurred in 3%-6% of patients.
Authors
- Ilana Moffet
- Naoko Kono
- Andrea Hahn (ORCID: https://orcid.org/0000-0002-5117-0080)
- Christopher J. Russell (ORCID: https://orcid.org/0000-0002-5269-7861)
- Margaret Rush (ORCID: https://orcid.org/0000-0001-6697-6207)
Institutions
- University of Southern California (US)
- Children's National (US)
- George Washington University (US)
- Stanford Medicine (US)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1097/inf.0000000000005080
- Primary Topic
- Tracheal and airway disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Agency for Healthcare Research and Quality
- National Center for Advancing Translational Sciences