Cancer cells transfer invasive properties through microRNAs contained in collagen tracks
Invasion is a prerequisite for metastasis formation. During tumor development, type I collagen overexpression increases tumor microenvironment stiffness, facilitating cancer cell dissemination. During breast cancer cell migration in 2D and 3D matrices, we observed membrane debris left behind, attached to the collagen fibrils, along the migration path. We named these structures collagen -tracks. Their formation is stimulated by the interaction between the extracellular matrix (ECM) and matrix receptors, such as discoidin domain receptor 1 (DDR1). They present a specific nucleic acid and protein contents. When deposited by highly invasive breast cancer cells, internalized collagen tracks reprogram non-invasive cells into highly pro-metastatic ones, increasing their ECM degradation and invasive capacities. This cell reprogramming is dependent on specific microRNAs (miRNAs) identified in the collagen tracks. Collagen tracks thus represent a form of cell-cell communication important for driving tumor invasion that could be targeted to prevent metastasis.
Authors
- Sisareuth Tan (ORCID: https://orcid.org/0000-0003-3633-6318)
- Frédéric Saltel (ORCID: https://orcid.org/0000-0002-0724-9680)
- Julie Giraud (ORCID: https://orcid.org/0000-0001-6173-4276)
- Lucile Rouyer
- Cyril Dourthe (ORCID: https://orcid.org/0000-0002-0941-1303)
- Gaëtan MacGrogan
- Alexandre Favereaux (ORCID: https://orcid.org/0000-0003-0881-9224)
- Manon Ros (ORCID: https://orcid.org/0000-0001-7878-3613)
- Jean‐William Dupuy (ORCID: https://orcid.org/0000-0002-2448-4797)
- Léa Normand
- Violaine Moreau (ORCID: https://orcid.org/0000-0002-4513-7022)
- Richard Iggo (ORCID: https://orcid.org/0000-0002-8822-9111)
- Sylvaine Di-Tommaso (ORCID: https://orcid.org/0000-0003-4507-2844)
- Nathalie Allain
- Nathalie Dugot‐Senant
- Reini F. Luco (ORCID: https://orcid.org/0000-0002-9086-6507)
- Kévin Moreau (ORCID: https://orcid.org/0000-0002-3688-3998)
- Anthony Bouter (ORCID: https://orcid.org/0000-0002-0068-2780)
- Anne‐Aurélie Raymond (ORCID: https://orcid.org/0000-0003-2697-9352)
- Élodie Richard (ORCID: https://orcid.org/0000-0003-3778-1210)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Institut des Neurosciences Paris-Saclay (FR)
- Institut des Sciences des Plantes de Paris Saclay (FR)
- Bordeaux Population Health (FR)
- Institut Interdisciplinaire de Neuroscience (FR)
- Chimie et Biologie des Membranes et des Nanoobjects (FR)
- Institut Polytechnique de Bordeaux (FR)
- Institut Curie (FR)
- Saft (France) (FR)
Publication Details
- Journal
- Cell Reports
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.celrep.2025.116725
- Citations
- 1
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 1.62