Development and Validation of an Intratumor Heterogeneity–Based Prognostic Model for Clear Cell Renal Cell Carcinoma
We developed and validated the ITHscore, a three-gene expression-based model with superior prognostic performance in ccRCC. The ITHscore reflects key features of aggressiveness in tumor biology, including immune evasion and ICB resistance. Its minimal gene set and consistent performance across data sets support its potential for clinical implementation in ccRCC stratification.
Authors
- Carlos Diego Holanda Lopes (ORCID: https://orcid.org/0000-0003-4988-644X)
- L Park (ORCID: https://orcid.org/0009-0000-6088-6948)
- Giuseppe G. F. Leite (ORCID: https://orcid.org/0000-0003-1848-4480)
- Erick Figueiredo Saldanha (ORCID: https://orcid.org/0000-0001-7972-4244)
- Mariana Macambira Noronha (ORCID: https://orcid.org/0000-0003-0889-7425)
- Valbert Oliveira Costa Filho (ORCID: https://orcid.org/0009-0003-2864-0966)
- Pedro Robson Costa Passos
Institutions
- Universidade Federal do Ceará (BR)
- Princess Margaret Cancer Centre (CA)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1200/po-25-00709
- Citations
- 1
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52