S2230 Predictors of Same Day Discharge Following Peroral Endoscopic Myotomy in a Tertiary Care Center

Introduction: Peroral Endoscopy Myotomy (POEM) has revolutionized management of achalasia, with same-day discharge (SDD) gaining interest to reduce healthcare utilizations. However, standardized post-procedural care protocols and discharge timing remain undefined. Our study aims to identify predictive factors of successful SDD. Methods: This single-center, single-operator retrospective study included patients undergoing esophageal POEM for achalasia between August 2023-April 2025. Multivariate analysis was performed to identify clinical and procedure related predictors of successful SDD. Results: Eighty patients were included in the study (mean age 58.3, 57.5% man). Baseline characteristics were similar. Procedure duration was significantly shorter (32 vs 42 min, P 0.002) in SDD patients compared to admitted patients. Anesthesia sedation or analgesia requirements were similar across both groups. Patients in the SDD group reported significantly lower pain scores at entry (4.5 vs 6.3, P 0.021) and exit (2.5 vs 5.9, P < 0.0001), and had shorter PACU stays (188 vs 239 mins, P 0.004). A total of 55 (68.75%) patients were discharged the same day. Among the 25 (31.25%) patients admitted, reasons included postprocedural pain (n = 6), pneumonia (n = 3), pneumonia and pleural effusion (n- = 1), intraprocedural pneumothorax requiring chest tube (n = 1), postprocedural pneumothorax (n = 1) and observation (n = 13). Among SDD patients, 5 patients made phone calls for pain and 2 patients visited the ED for the same. One patient reported persistent dysphagia needing EGD. All adverse events were mild, except for 1 moderate event involving persistent dysphagia requiring repeat EGD. On univariable analysis, positive predictors of SDD included procedure duration < 32 minutes (OR 5.29, P 0.002) and use of topical lidocaine (OR 3.86, P 0.010). Poorly controlled pain at end of PACU monitoring (visual analog score (VAS) ≥ 4) negatively predicted SDD (OR 0.09, P < 0.001). Multivariable modeling confirmed, topical lidocaine (OR 6.22, P 0.026) and VAS ≥ 4 (OR 0.1, P 0.010) as independent predictors. Upon sub-group analysis of patients with VAS ≥ 4, topical lidocaine was the sole predictor of SDD (OR = 15.88, P 0.004). Conclusion: Procedure duration and topical lidocaine use increase the likelihood of discharge, while poor pain control predicts admission. Standardizing lidocaine patches within the perioperative protocol may enhance analgesia management and facilitate safe and efficient discharge.