Synthesis, Characterization, and Enhanced Antibacterial Properties of Nanocomposites Based on Cu, Ag, and Au Nanoparticles Supported on the Coordination Polymer [Zn ₂ (1,3‐bdc)(Bzim) ₂ ]

ABSTRACT Nanocomposites combining the coordination polymer [Zn 2 (1,3‐bdc)(Bzim) 2 ] as support with metallic nanoparticles—Cu (0.13 wt %), Ag (0.028 wt %), or Au (0.092 wt %)—were successfully synthesized using the “ship‐in‐bottle” method, and characterized by XRD, SEM, TEM, FTIR, ICP‐OES, and BET. The incorporation of MNPs did not alter the stability and structure of the support. In the evaluation of biocidal agents, nanocomposites showed enhanced bactericidal activity by up to thirteen times compared to MNPs without support and up to sixteen times regarding the antibiotic amoxicillin. Furthermore, the cytotoxicity of the materials was evaluated in fibroblasts and macrophages using the MTT assay. Our findings indicate that the cytotoxicity of MNPs/[Zn 2 (1,3‐bdc)(Bzim) 2 ] materials is dose‐dependent. At concentrations ≤ CC50, these nanomaterials exhibited excellent cytocompatibility. Notably, the Ag‐based nanocomposite demonstrated significant antibacterial activity without substantial cytotoxicity, even at higher doses.