Decoding ALS from the tail end of RNA
In this issue of Cell Genomics, McKeever et al.<sup>1</sup> generate a single-nucleus transcriptomic atlas of ALS/FTLD brain and reveal widespread alternative polyadenylation changes. Their findings highlight 3' end RNA processing as a central integrator of stress responses, cell-type specificity, and disease susceptibility, offering new mechanistic insight and potential therapeutic directions.
Authors
- Yusuke Fujioka (ORCID: https://orcid.org/0009-0007-6321-4494)
- Shinsuke Ishigaki (ORCID: https://orcid.org/0000-0002-9555-0659)
Institutions
- Shiga University of Medical Science (JP)
- Shiga University (JP)
Publication Details
- Journal
- Cell Genomics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.xgen.2025.101102
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00