Sex-specific cardiac ageing and sympathetic compensation: a translational study
Age-related cardiac changes affect both women and men in similar ways, but are more pronounced in women-likely reflecting a greater decline in sex hormones. This is associated with more prominent compensatory mechanisms to offset their disadvantage of having a smaller heart. Animal and tissue models support these findings by revealing hormone- and sex-specific effects on cardiac structure and sympathetic regulation.
Authors
- Ahmed Haider (ORCID: https://orcid.org/0000-0002-5204-4473)
- Linjing Mu (ORCID: https://orcid.org/0000-0001-5354-1546)
- Bruno Weber (ORCID: https://orcid.org/0000-0002-9089-0689)
- Sebastian Kozerke (ORCID: https://orcid.org/0000-0003-3725-8884)
- Alexander Gaudl (ORCID: https://orcid.org/0000-0002-7197-3868)
- Cathérine Gebhard (ORCID: https://orcid.org/0000-0001-7240-5822)
- Uta Ceglarek (ORCID: https://orcid.org/0000-0002-4034-5535)
- Giuseppe Vassalli (ORCID: https://orcid.org/0000-0002-6378-5883)
- Susan Bengs (ORCID: https://orcid.org/0000-0003-2424-3894)
- Muriel Grämer
- Alexia Rossi (ORCID: https://orcid.org/0000-0001-6845-1199)
- Caroline E. Gebhard
- Ronald Biemann (ORCID: https://orcid.org/0000-0002-0820-8231)
- Philipp Antonio Kaufmann (ORCID: https://orcid.org/0000-0002-9451-5210)
- Simon M. Ametamey
- Sandro Fröhlich
- Dominik Etter (ORCID: https://orcid.org/0000-0002-7060-6089)
- Christoph Gräni (ORCID: https://orcid.org/0000-0001-6029-0597)
- Ronny R. Buechel (ORCID: https://orcid.org/0000-0001-8064-8904)
- Giovanni G. Camici (ORCID: https://orcid.org/0000-0002-0523-0695)
- Vera Regitz‐Zagrosek (ORCID: https://orcid.org/0000-0002-3566-3467)
- Monika Marędziak (ORCID: https://orcid.org/0000-0002-7281-9272)
- Madlen Reinicke (ORCID: https://orcid.org/0000-0003-3864-6424)
- Pimrapat Gebert (ORCID: https://orcid.org/0000-0002-5946-7137)
- Alexander Akhmedov (ORCID: https://orcid.org/0000-0003-3052-9493)
- Carolina Balbi (ORCID: https://orcid.org/0000-0002-7394-1173)
- Grzegorz Kwiatkowski (ORCID: https://orcid.org/0000-0001-6783-3590)
- Geoffrey Warnock
- Nidaa Mikaïl (ORCID: https://orcid.org/0000-0003-4896-1428)
- Alexander Meisel (ORCID: https://orcid.org/0000-0003-2422-1281)
- Claudia Keller (ORCID: https://orcid.org/0000-0001-7736-9680)
- Adrienne Müller Herde (ORCID: https://orcid.org/0000-0002-8931-1619)
- Angela Portmann (ORCID: https://orcid.org/0000-0002-0973-5439)
Institutions
- University of Zurich (CH)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- ETH Zurich (CH)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- Institute for Biomedical Engineering (CH)
- Zimmer Biomet (Germany) (DE)
- University Hospital of Zurich (CH)
- Molecular Partners (Switzerland) (CH)
- Repubblica e Cantone Ticino (CH)
- University Hospital Leipzig (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-11-09
- DOI
- https://doi.org/10.1093/eurheartj/ehaf922
- Citations
- 1
- Primary Topic
- Heart rate and cardiovascular health
- Type
- article
- Field-Weighted Citation Impact
- 1.39