S2017 Increasingly High Prevalence of Advanced Therapy Use in Patients With Ulcerative Colitis in a Large Community and Academic Cohort: A Preliminary Analysis From IBD Qorus

Introduction: Underuse of advanced therapies (AT) in ulcerative colitis (UC) may contribute to suboptimal outcomes. We aimed to describe AT utilization within IBD Qorus, a large multicenter learning health system, and investigate factors associated with AT use. Methods: Patient and provider survey responses from IBD Qorus were collected prospectively from November 2020 to May 2025 at 48 academic and community sites during routine clinical visits. We included visits with recorded current medication use and IBD classification of UC. We report descriptive statistics and a multivariable logistic regression with variable selection using the backward Wald method to identify factors associated with AT use. Differences in PRO2 between patients using vs not using AT were assessed with the Mann–Whitney U test. We additionally measured the rates of AT use in UC visits over time in 6 month intervals. Results: Patient and provider survey responses from IBD Qorus were collected prospectively from November 2020 to May 2025 at 48 academic and community sites during routine clinical visits. We included visits with recorded current medication use and IBD classification of UC. We report descriptive statistics and a multivariable logistic regression with variable selection using the backward Wald method to identify factors associated with AT use. Differences in PRO2 between patients using vs not using AT were assessed with the Mann–Whitney U test. We additionally measured the rates of AT use in UC visits over time in 6 month intervals. Conclusion: In this large cohort encompassing both community and academic sites, AT was used in over half of all ulcerative colitis visits. To our knowledge, this prevalence exceeds that reported in other cohorts, possibly due to cohort members’ interest in IBD or participation in the IBD Qorus collaborative. Our data also reveal a trend of increasing AT use among UC patients. Future research should investigate how advanced therapy utilization evolves over time and across different clinical settings—particularly with respect to patient outcomes—to better guide and optimize the use of these treatments.