Adult Acute Myeloid Leukaemia With <i>DDX3X::MLLT10</i> : A Rare Entity With Significant Unmet Clinical Needs

DDX3X:<i>:MLLT10</i>¸ which arises from t(X;10)(p11.4;p12.31), is infrequently observed in adult acute myeloid leukaemia (AML). The clinical and pathological characteristics are also not well characterised, detailed in only two cases published to date. This third case reports the fusion gene in a 27-year-old female with acute myelomonocytic leukaemia (AMML) with refractoriness to multiple lines of chemotherapy. Collectively, these cases highlight the genomic heterogeneity of this rare entity, as well as significant unmet clinical needs due to the poor prognosis and chemoresistance observed. These findings may inform future iterations of AML classification and prognostication in adults.