Anatomical distribution of disease in pN1 prostate cancer with BCR post‐RP: A PSMA‐PET/CT‐based analysis
PSMA-PET/CT identified PSMA-expressing recurrent disease in nearly half of pN1 PCa patients at early BCR, with about half confined to the pelvis and a quarter beyond the pelvis. These anatomical patterns indicate that PSMA-PET/CT can inform risk-adapted salvage strategies, including pelvic radiotherapy for nodal recurrences and systemic treatment when disease extends beyond the pelvis.
Authors
- Harm H.E. van Melick (ORCID: https://orcid.org/0000-0001-9285-0632)
- Henk G. van der Poel (ORCID: https://orcid.org/0000-0002-8772-1120)
- Wouter V. Vogel (ORCID: https://orcid.org/0000-0002-4992-8024)
- K.C.C. de Bie (ORCID: https://orcid.org/0000-0002-6892-8943)
- Daniela E. Oprea‐Lager (ORCID: https://orcid.org/0000-0001-9447-2305)
- Maarten L. Donswijk (ORCID: https://orcid.org/0000-0003-2028-9713)
- Lieke Wever (ORCID: https://orcid.org/0000-0003-0033-4089)
- Pim J. van Leeuwen (ORCID: https://orcid.org/0000-0002-5531-6104)
- Anne‐Claire Berrens (ORCID: https://orcid.org/0000-0002-3328-384X)
- Jean‐Paul A. van Basten (ORCID: https://orcid.org/0000-0002-8149-5599)
- André N. Vis (ORCID: https://orcid.org/0000-0003-3419-3368)
- L. Zuur (ORCID: https://orcid.org/0009-0000-7392-1626)
Institutions
- Radboud University Nijmegen (NL)
- Dutch Cancer Society (NL)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- St. Antonius Ziekenhuis (NL)
- Oncode Institute (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- BJUI Compass
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/bco2.70123
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00