S1843 Age and Sex Disparities in the Prevalence of Coronary Artery Disease Among Hospitalized Patients With Inflammatory Bowel Disease

Introduction: Although inflammatory bowel disease (IBD) is usually diagnosed in early adulthood, as the population ages, cardiovascular comorbidities such as coronary artery disease (CAD) are increasingly encountered in hospitalized patients with IBD. Although CAD is more prevalent among men in the general population, the impact of sex and age on CAD prevalence within the IBD population remains underexplored. We aimed to evaluate how age and sex correlate with the presence of CAD among hospitalized patients with IBD using a national dataset. Methods: We performed a retrospective cross-sectional analysis of 4,142,365 IBD-related hospitalizations from the National Inpatient Sample (2016–2019), identified using International Classification of Diseases-10 codes. Patients were stratified by the presence of CAD. Primary outcomes were mean age at admission and sex distribution. Group comparisons were performed using t-tests and Chi-square analysis, with statistical significance defined as P < 0.001. Results: CAD was present in 842,658 (20.3%) of all IBD-related hospitalizations. Patients with CAD were significantly older, with a mean age of 73.7 ± 11.4 years compared to 61.7 ± 18.0 years in those without CAD (P < 0.001), reflecting a 12-year absolute difference. Sex distribution also varied significantly by CAD status. Among IBD patients with CAD, 54.1% were men (n = 455,711) and 45.9% were women (n = 386,947), whereas in the non-CAD group, only 40.2% were men (n = 1,325,609) and 59.8% were women (n = 1,973,338). This represents a relative increase in the proportion of males among CAD patients compared to non-CAD patients, with the difference being statistically significant (Chi-square = 52,942, df = 1, P < 0.001). Conclusion: Our findings reveal that hospitalized patients with IBD and concomitant CAD are significantly older and more likely to be men compared to their non-CAD counterparts. The observed difference in age underscores the cumulative cardiovascular burden in aging IBD populations, while the male predominance highlights potential sex-based differences in inflammatory response, cardiovascular risk factor distribution, and healthcare utilization. These disparities emphasize the need for proactive cardiac risk assessment, particularly in older males with IBD, and support the integration of geriatric and cardiovascular care strategies within IBD management. Future research should assess whether age- and sex-related interventions can improve outcomes in this population.