Enhanced glioblastoma immunotherapy via SMAC mimetic dose escalation and TGFβ blockade
We comprehensively outline how SMCs can be used in conjunction with ICIs to treat GBM and propose strategies to maximize SMC efficacy.
Authors
- Shawn T. Beug (ORCID: https://orcid.org/0000-0002-9991-3306)
- Robert G. Korneluk (ORCID: https://orcid.org/0000-0002-5675-646X)
- Eric C. LaCasse (ORCID: https://orcid.org/0000-0003-2338-1857)
- Kyle Malone (ORCID: https://orcid.org/0000-0002-9933-7302)
- Tommy Alain (ORCID: https://orcid.org/0000-0002-0396-9138)
- Nathalie Earl
- Melanie Dugas
Institutions
- University of Ottawa (CA)
- Children's Hospital of Eastern Ontario (CA)
- Institute of Infection and Immunity (CA)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1093/noajnl/vdaf253
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Ottawa
- Mitacs
- Hospital for Sick Children
- Canadian Institutes of Health Research
- Canadian Cancer Society Research Institute