Identification of Crohn’s disease subtypes in single-cell RNA sequencing signatures of treatment-naive samples across the pediatric gastrointestinal tract
Tensor decomposition stratified donors into clinically meaningful groups based on their transcriptomic profile, suggesting these signatures can be utilized for personalized medicine.
Authors
- Sushma Chowdary Maddipatla
- Vasantha L. Kolachala (ORCID: https://orcid.org/0009-0005-6919-3765)
- Greg C. Gibson (ORCID: https://orcid.org/0000-0002-5352-5877)
- Peng Qiu (ORCID: https://orcid.org/0000-0003-3256-0734)
- Yeonjoo Hwang (ORCID: https://orcid.org/0000-0002-3000-4710)
- Shanta Murthy
- Tarun Koti
- Subra Kugathasan
- Savannah Washburn
Institutions
- Georgia Institute of Technology (US)
- Emory University (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf225
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00