Determinants of respiratory tract aerosol generation in a diverse clinical population: an observational study
Our measurement of respiratory aerosol generation from patients with lung disease and infection is comparable with those published previously for healthy subjects. The amount of aerosol generation across the studied population was most closely linked with expiratory flow. While we observed variation in respiratory aerosol generation between participants in a clinical environment, there was no meaningful impact of demographics or respiratory disease on aerosol generation.
Authors
- Umair Syed Mahmud
- Bryan R. Bzdek (ORCID: https://orcid.org/0000-0003-2234-1079)
- George William Nava (ORCID: https://orcid.org/0000-0002-7153-8065)
- James Dodd (ORCID: https://orcid.org/0000-0003-4805-5759)
- Fergus Hamilton (ORCID: https://orcid.org/0000-0002-9760-4059)
- L. Y. ng
- Dinesh Saralaya (ORCID: https://orcid.org/0000-0002-7606-0056)
- Nick Maskell (ORCID: https://orcid.org/0000-0002-1276-6500)
- Jonathan P. Reid (ORCID: https://orcid.org/0000-0001-6022-1778)
- Sujoy Khan (ORCID: https://orcid.org/0000-0001-5654-2835)
- Alicja Szczepańska (ORCID: https://orcid.org/0000-0002-7829-6978)
- Rachel Scott (ORCID: https://orcid.org/0000-0002-4506-1945)
Institutions
- North Bristol NHS Trust (GB)
- University of Bradford (GB)
- University of Bristol (GB)
- NIHR Bristol Biomedical Research Centre (GB)
Publication Details
- Journal
- BMJ Open Respiratory Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1136/bmjresp-2025-003494
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- NIHR Bristol Biomedical Research Centre
- National Institute for Health and Care Research
- Medical Research Council