A Single Cell Atlas of the Newt Iris During Lens Regeneration
Cell atlas identifying cells in the newt iris at multiple timepoints during lens regenerationIntact iris contains multiple iris pigmented epithelial (IPE) cell subpopulationsIdentification of IPE functional states during regenerationCellular trajectory analysis revealed a molecular and genetic blueprint of IPE-to-lens epithelial cell reprogrammingIdentification of cell-to-cell interactions between IPE cells and other cell typesMacrophages interacting with IPE cells are tissue-resident and polarize from M1 to M2 subtypes during lens regeneration.
Authors
- Konstantinos Sousounis (ORCID: https://orcid.org/0000-0002-5577-6207)
- Disha Hegde
- Bruce Wallace (ORCID: https://orcid.org/0000-0003-0360-7302)
- Joseph L. Sevigny (ORCID: https://orcid.org/0000-0003-0024-3718)
- Olivia M. Williams (ORCID: https://orcid.org/0009-0004-1457-4854)
- W. Kelley Thomas (ORCID: https://orcid.org/0000-0002-0945-5269)
- Timothy Ralich
- Nicole Farber
- Kenneth J. Lampel
- Leo Napoleon
- Jacob Nipoti
- Kelsey E. Ahearn
- Jenna Loporcaro
Institutions
- University of New Hampshire at Manchester (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-09
- DOI
- https://doi.org/10.64898/2025.12.06.692619
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00