Chloroprocaine ED50 and ED95 for Propofol Injection Pain Prevention: Dixon’s Sequential Method
Intravenous CP, administered at doses of 11.554 mg and 13.085 mg, achieved 50% and 95% efficacy, respectively, in preventing pain associated with propofol injection. These doses were associated with effective attenuation of nociceptive responses, reduced propofol requirements, absence of significant adverse effects, and preservation of hemodynamic stability, thereby supporting the use of CP in enhancing patient comfort during anesthetic induction.
Authors
- Benjamin Chen (ORCID: https://orcid.org/0009-0002-9060-5136)
- Guangfen Yin (ORCID: https://orcid.org/0000-0002-4852-0158)
- Paul B.S. Lai (ORCID: https://orcid.org/0000-0002-9469-6728)
- Yanwei Fang
- Xuemei Yang
- Qinghang Xuan (ORCID: https://orcid.org/0000-0002-8113-7134)
- Zhijiao He (ORCID: https://orcid.org/0009-0008-1798-8066)
- Xiyang Yang (ORCID: https://orcid.org/0000-0002-2582-6875)
Institutions
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Gaozhou People's Hospital (CN)
- Dali University (CN)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jpr.s553084
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00