pH-dependent efficacy of nitrofurantoin against uropathogenic Escherichia coli: Implications for personalized urinary tract infection treatment
Nitrofurantoin exhibits pronounced pH-dependent activity, with acidic environments enhancing its bactericidal efficacy against UPEC. Current susceptibility testing at neutral pH may underestimate the in vivo performance. Integrating urinary pH considerations into antimicrobial susceptibility testing and patient management could optimize the treatment outcomes and support personalized UTI therapy.
Authors
- Zinnu Rain (ORCID: https://orcid.org/0000-0002-8293-9921)
- Shivendra Kumar Singh (ORCID: https://orcid.org/0000-0001-7994-0561)
- Sumit Rai (ORCID: https://orcid.org/0000-0002-6494-0742)
- Pradyot Prakash (ORCID: https://orcid.org/0000-0003-3622-4295)
- Deepak Kumar (ORCID: https://orcid.org/0000-0003-3785-4213)
- A. Mukhopadhyay (ORCID: https://orcid.org/0000-0002-3879-5262)
Institutions
- Institute of Medical Sciences (IN)
- Indian Institute of Technology BHU (IN)
- All India Institute of Medical Sciences (IN)
- Banaras Hindu University (IN)
Publication Details
- Journal
- Indian Journal of Urology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.4103/iju.iju_255_25
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00