Hydroxylated iodinated boron clusters: a tunable platform for enhanced membrane transport and biocompatibility
[B<sub>12</sub>I<sub>12</sub>]<sup>2-</sup> exhibits potent membrane transport yet high cytotoxicity. Stepwise hydroxylation moderates chaotropicity, balancing permeability and biocompatibility. Notably, mono-hydroxylation retains transport activity while minimizing toxicity, whereas further hydroxylation ablates permeability. This strategy advances safe, efficient boron cluster-based carriers for drug delivery and related biomedical applications.
Authors
- Yumiko Kawamura (ORCID: https://orcid.org/0000-0001-8812-4005)
- Y Kitazawa (ORCID: https://orcid.org/0000-0002-3238-4251)
- Yoshimasa Makita (ORCID: https://orcid.org/0000-0003-4732-8145)
- Taro Kitazawa (ORCID: https://orcid.org/0000-0002-3377-493X)
- Mutsumi Kimura (ORCID: https://orcid.org/0000-0003-3050-8254)
- Yuya Hirai (ORCID: https://orcid.org/0000-0001-8571-080X)
- Satoshi Yamamoto (ORCID: https://orcid.org/0000-0001-8278-4467)
- Ryota Nakajima (ORCID: https://orcid.org/0000-0003-1708-7109)
Institutions
- Shinshu University (JP)
- Aarhus University (DK)
- Osaka Dental University (JP)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1039/d5cc04085j
- Primary Topic
- Boron Compounds in Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00