S-Nitrosylation of Pyruvate Kinase Isoform 2 Drives Cardiac Fibrosis by Promoting Mitochondrial Fission
SNO-PKM2 specifically increases in cardiac fibroblasts and activated cardiac fibroblasts by inducing excessive mitochondrial fission through a gelsolin-dependent manner. Mitapivat is a potential therapeutic option for attenuating cardiac fibrosis.
Authors
- Yi Han (ORCID: https://orcid.org/0000-0002-2334-5779)
- Ke Zhong (ORCID: https://orcid.org/0000-0003-3664-9234)
- Yong Ji (ORCID: https://orcid.org/0000-0003-2650-5747)
- Bo Yu (ORCID: https://orcid.org/0000-0002-5955-6332)
- Changhao Sun (ORCID: https://orcid.org/0000-0001-9416-7044)
- Yu Wang (ORCID: https://orcid.org/0000-0001-9357-9119)
- Xin Chen (ORCID: https://orcid.org/0000-0001-5518-3922)
- Danyu Ye
- Xiangqing Kong (ORCID: https://orcid.org/0000-0003-3309-1140)
- Zhengrong Huang (ORCID: https://orcid.org/0000-0003-0007-9321)
- Mengqi Lv (ORCID: https://orcid.org/0000-0002-1326-3227)
- Miao Zhou (ORCID: https://orcid.org/0000-0002-5463-4784)
- Liping Xie (ORCID: https://orcid.org/0000-0001-6440-0239)
- Yan Zhang
- Shanshan Luo (ORCID: https://orcid.org/0000-0002-3884-4095)
- Zhi‐Ren Zhang (ORCID: https://orcid.org/0000-0003-1324-6934)
- Lulu Hu (ORCID: https://orcid.org/0000-0002-2008-3996)
- X. Wang (ORCID: https://orcid.org/0000-0003-3324-1954)
- Shan-zhen Sun (ORCID: https://orcid.org/0000-0003-2264-4141)
Institutions
- Harbin Medical University (CN)
- World Wide Web Consortium (US)
- First Affiliated Hospital of Xiamen University (CN)
- Ministry of Education (KR)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Heilongjiang University (CN)
- ZTE (United States) (US)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1161/circulationaha.125.075903
- Citations
- 1
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 1.39