<i>Tert</i> Deletion Impairs Circadian Regulation of Blood Pressure in Male Spontaneously Hypertensive Rats
Our results suggest that deletion of <i>Tert</i> impairs circadian regulation of blood pressure via a decreased rhythm of sympathetic activity innervating the heart and other tissues, leading to impaired circadian regulation of local peripheral clocks. These findings provide a possible link between age-related telomere shortening and impaired rhythmicity of cardiovascular function.
Authors
- Dmytro Semenovykh (ORCID: https://orcid.org/0000-0001-9957-0676)
- Michal Pravenec (ORCID: https://orcid.org/0000-0001-9197-5871)
- Saba Selvi (ORCID: https://orcid.org/0000-0002-6965-1384)
- Kateryna Semenovykh (ORCID: https://orcid.org/0000-0002-7827-2079)
- Miroslava Šimáková (ORCID: https://orcid.org/0000-0003-1468-5832)
- Jan Šilhavý (ORCID: https://orcid.org/0000-0001-8042-5890)
- František Liška (ORCID: https://orcid.org/0000-0002-9588-806X)
- Petr Mlejnek (ORCID: https://orcid.org/0000-0002-4218-8983)
- Martin Sládek (ORCID: https://orcid.org/0000-0002-9744-9386)
- Alena Sumová (ORCID: https://orcid.org/0000-0003-4126-5470)
- Ivana Vaněčková
- Silvie Hojná
- Pavel Houdek (ORCID: https://orcid.org/0000-0002-0746-9384)
Institutions
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Animal Physiology and Genetics (CZ)
- Czech Academy of Sciences, Institute of Experimental Medicine (CZ)
- Norwegian Womens Public Health Association (NO)
- General University Hospital in Prague (CZ)
- Czech Academy of Sciences, Institute of Physiology (CZ)
Publication Details
- Journal
- Hypertension
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25510
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00