NADPH Oxidase 4 and Metabolic Stress in Dahl Salt-Sensitive Rat Kidneys
NOX4-derived reactive oxygen species were linked to less favorable metabolic responses to salt loading in SS hypertension. NOX4 deletion was associated with a more protective, fatty acid oxidation-driven metabolic profile. These findings highlight redox-sensitive metabolic reprogramming as a potential therapeutic target in hypertension and chronic kidney disease.
Authors
- Timothy J. Stodola (ORCID: https://orcid.org/0000-0001-9671-884X)
- Satoshi Shimada (ORCID: https://orcid.org/0000-0001-5293-572X)
- Theresa Kurth (ORCID: https://orcid.org/0000-0002-6061-8289)
- Ranjan K. Dash (ORCID: https://orcid.org/0000-0001-6751-0679)
- Allen W. Cowley (ORCID: https://orcid.org/0000-0002-0801-6248)
- Mingyu Liang (ORCID: https://orcid.org/0000-0002-6970-989X)
- Brian Hoffmann (ORCID: https://orcid.org/0000-0002-7526-6335)
- Chun Yang (ORCID: https://orcid.org/0000-0003-3307-1609)
Institutions
- Marquette University (US)
- University of Arizona (US)
- Medical College of Wisconsin (US)
- Jackson Laboratory (US)
Publication Details
- Journal
- Hypertension
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25718
- Citations
- 2
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.33