Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition
In summary, ALM attenuates inflammatory crosstalk between M1 macrophages and adipocytes by enhancing SIRT3-mediated mitophagy and suppressing NLRP3 inflammasome activation, thereby alleviating adipose tissue inflammation and pathological remodeling in obesity. Thus, ALM has the capacity to become a therapeutic candidate for treating obesity and its associated metabolic disorders.
Authors
- Lidan Hu (ORCID: https://orcid.org/0000-0002-1145-2745)
- Lei Tang (ORCID: https://orcid.org/0009-0009-2169-8704)
- Ai Tian (ORCID: https://orcid.org/0009-0000-1849-0624)
- Ke‐Gang Linghu (ORCID: https://orcid.org/0000-0002-0406-5894)
- Yüxia Zhou (ORCID: https://orcid.org/0000-0002-6579-6068)
- Ligen Lin (ORCID: https://orcid.org/0000-0002-6799-5327)
- Tian Zhang (ORCID: https://orcid.org/0000-0002-4871-1771)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0002-6693-643X)
- Lirong Liu (ORCID: https://orcid.org/0009-0006-9942-9166)
- Mingjun Shi (ORCID: https://orcid.org/0000-0003-2833-9201)
- Hua Yu (ORCID: https://orcid.org/0000-0001-6691-1139)
- Yu-E Wang
- Bing Guo
Institutions
- Guiyang Medical University (CN)
- University of Macau (MO)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1186/s13020-025-01253-4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00