Rumen microbial dysbiosis is associated with productive lifespan decline in dairy cows via metabolic-inflammatory crosstalk
Longitudinal analyses classify rumen microbial dysbiosis as a potential driver of reduced productive longevity and lactation performance decline in dairy cows, suggesting that the temporal dynamics of the rumen microbiota influence lactation persistence and productive lifespan. This study fills the gap in microbiota-targeted strategies to extend dairy cows' productive longevity through precision microbial consortium modulation. Video Abstract.
Authors
- Shuai Qin (ORCID: https://orcid.org/0000-0001-7708-9558)
- Yuefei Yan (ORCID: https://orcid.org/0000-0002-6951-0661)
- Jingbo Dai (ORCID: https://orcid.org/0000-0001-7562-9039)
- Shanshan Gao
- Changlei Liu
- Suyi Gu
- Chaoying Huang
- Panping Yang
- Yang Zhang (ORCID: https://orcid.org/0000-0002-6804-1840)
- Yaqin Wang (ORCID: https://orcid.org/0000-0001-8469-1256)
- Huixia Li (ORCID: https://orcid.org/0000-0001-8566-7143)
- Yujia Li (ORCID: https://orcid.org/0000-0001-7510-8954)
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-3764-792X)
- Feng Zhou (ORCID: https://orcid.org/0000-0003-2252-7981)
- Xiaoli Ren (ORCID: https://orcid.org/0009-0005-1656-0840)
- Lei Yan (ORCID: https://orcid.org/0000-0001-8603-5412)
- Zhuoxuan Wu
- Zhiyang Zhang (ORCID: https://orcid.org/0009-0004-4057-7098)
Institutions
- Nanjing Agricultural University (CN)
- Henan Provincial Institute of Occupational Health (CN)
- Henan Energy & Chemical Industry Group (China) (CN)
- Henan Provincial Health Bureau (CN)
- Zhengzhou Institute of Machinery (CN)
- Henan University of Economic and Law (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1186/s40168-025-02263-y
- Primary Topic
- Ruminant Nutrition and Digestive Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00