Clinical outcomes following stereotactic <scp>MRI</scp> ‐guided laser ablation in children with tuberous sclerosis complex and intractable epilepsy
SLA was safe and effective for most patients, even the very young. A majority of patients achieved improvement in seizure frequency, including the surgically targeted seizure type, but less than half were able to reduce medications. Reported developmental improvement was related to Engel outcomes. Future studies utilizing neuropsychological testing in the full cohort will be required to offer objective insights into post-operative development profiles.
Authors
- Yingchao Yuan (ORCID: https://orcid.org/0000-0002-8583-0032)
- Anuranjita Nayak (ORCID: https://orcid.org/0000-0001-5618-3342)
- Vijay M. Ravindra (ORCID: https://orcid.org/0000-0002-4496-7622)
- James J. Riviello (ORCID: https://orcid.org/0000-0002-4399-0257)
- Kimberly Houck (ORCID: https://orcid.org/0000-0003-4587-7837)
- Sonali Sen (ORCID: https://orcid.org/0009-0004-4943-6814)
- Deepankar Mohanty (ORCID: https://orcid.org/0009-0003-1261-6718)
- Gloria Diaz‐Medina (ORCID: https://orcid.org/0000-0002-6053-4982)
- Daniel J. Curry (ORCID: https://orcid.org/0000-0003-3661-2976)
- Irfan Ali (ORCID: https://orcid.org/0000-0003-1760-1788)
- Anne E. Anderson (ORCID: https://orcid.org/0000-0001-7639-2504)
- Kalman A. Katlowitz
- Akshat Katyayan (ORCID: https://orcid.org/0000-0001-6980-8292)
- Dave Clarke (ORCID: https://orcid.org/0000-0002-9032-1291)
- Rohini Coorg (ORCID: https://orcid.org/0000-0003-0151-3361)
- Elaine Seto (ORCID: https://orcid.org/0000-0002-2650-4691)
- Howard L. Weiner (ORCID: https://orcid.org/0000-0003-0203-9681)
- Karen Evankovich (ORCID: https://orcid.org/0000-0002-1486-2475)
- Laura Masters
- Michael Quach
- Danielle Schwartzenburg Takacs (ORCID: https://orcid.org/0000-0001-6138-7200)
- Cristina Trandafir (ORCID: https://orcid.org/0000-0002-8624-7025)
- John T. Freiling (ORCID: https://orcid.org/0000-0002-6041-0373)
- Chelsey Ortman (ORCID: https://orcid.org/0009-0003-8671-4679)
Institutions
- Baylor College of Medicine (US)
- University of Utah (US)
- Texas Children's Hospital (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1111/epi.70036
- Citations
- 1
- Primary Topic
- Tuberous Sclerosis Complex Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16