Ionic-liquid-based aqueous biphasic systems meet microfluidics: from antibodies to aptamers in prostate-specific antigen detection
This work pioneers the combined use of IL-ABS pretreatment and aptamer-based microfluidic detection for PSA. Aptamers, as synthetic ligands, offer high specificity, enhanced stability, and flexible design, providing a cost-effective alternative to antibodies. Incorporating aptamer recognition enhances analytical performance relative to conventional antibody-based assays, highlighting the platform's potential for broader clinical and point-of-care applications.
Authors
- Mara G. Freire (ORCID: https://orcid.org/0000-0001-8895-0614)
- V. Chu (ORCID: https://orcid.org/0000-0002-5306-4409)
- Maria S.M. Mendes (ORCID: https://orcid.org/0000-0001-6631-9821)
- Francisca A. e Silva (ORCID: https://orcid.org/0000-0001-6735-5437)
- J. P. Conde (ORCID: https://orcid.org/0000-0002-5677-3024)
Institutions
- Instituto de Engenharia de Sistemas e Computadores Microsistemas e Nanotecnologias (PT)
- University of Aveiro (PT)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2025-12-10
- DOI
- https://doi.org/10.1016/j.aca.2025.345001
- Citations
- 1
- Primary Topic
- Ionic liquids properties and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.39