Fulminant Pneumocystis jirovecii pneumonia presenting as multi-organ dysfunction syndrome in an immunocompetent host

Present case describes an apparently healthy adult who developed severe Pneumocystis jirovecii pneumonia (PJP) leading to multiple organ dysfunction syndrome. The patient presented with month-long fever, fatiguability and recent onset dyspnoea, subsequently developing acute respiratory distress syndrome (ARDS), acute kidney injury and haematological complications. Definitive diagnosis was made through microscopic examination of P.jirovecii cysts stained by Grocott Gomori Methenamine Silver (GMS) and positive PCR assay of broncho-alveolar lavage fluid. This case highlights the evolving spectrum of PJP manifestations and emphasizes the need for early diagnosis and appropriate management in apparently immunocompetent hosts.

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Publication Details

Journal
Indian Journal of Medical Microbiology
Published
2025-12-10
DOI
https://doi.org/10.1016/j.ijmmb.2025.101037
Primary Topic
Pneumocystis jirovecii pneumonia detection and treatment
Type
article
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article

Fulminant Pneumocystis jirovecii pneumonia presenting as multi-organ dysfunction syndrome in an immunocompetent host

Debasish Biswal, Aayush Chawla, Rohit Kumar, Sadia Khan et al.
Indian Journal of Medical Microbiology
Pneumocystis jirovecii pneumonia detection and treatment
article

Fulminant Pneumocystis jirovecii pneumonia presenting as multi-organ dysfunction syndrome in an immunocompetent host

Debasish Biswal, Aayush Chawla, Rohit Kumar, Sadia Khan, Mohit Sharma, Sharmila Sengupta, Bijay Ranjan Mirdha, Anubhav Pandey, Anshuman Sengupta
article en

Abstract

Present case describes an apparently healthy adult who developed severe Pneumocystis jirovecii pneumonia (PJP) leading to multiple organ dysfunction syndrome. The patient presented with month-long fever, fatiguability and recent onset dyspnoea, subsequently developing acute respiratory distress syndrome (ARDS), acute kidney injury and haematological complications. Definitive diagnosis was made through microscopic examination of P.jirovecii cysts stained by Grocott Gomori Methenamine Silver (GMS) and positive PCR assay of broncho-alveolar lavage fluid. This case highlights the evolving spectrum of PJP manifestations and emphasizes the need for early diagnosis and appropriate management in apparently immunocompetent hosts.

Indian Journal of Medical MicrobiologyVol. 59
Amrita Institute of Medical Sciences and Research Centre (IN), All India Institute of Medical Sciences (IN), Amrita Vishwa Vidyapeetham (IN)
Openalex Percentile: Top 49%
Pneumocystis jirovecii pneumonia detection and treatment
DOIOpen Access PDFOpenAlex
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Fulminant Pneumocystis jirovecii pneumonia presenting as multi-organ dysfunction syndrome in an immunocompetent host — Debasish Biswal, Aayush Chawla, et al. · Indian Journal of Medical Microbiology (2025) | TGRS Research Map | TGRS