Photoredox/Nickel Dual-Catalyzed Asymmetric C-Alkylation of Nitroalkanes with α-Bromoketones
A stereoselective method for alkylating nitroalkanes with α-bromoketones using nickel/photoredox dual catalysis is described. The mild and functional-group-tolerant conditions allow the formation of complex and highly enantioenriched β-nitroketone products that hold promising utility as precursors for the formation of biologically relevant compounds.
Authors
- Raphael S. Kim (ORCID: https://orcid.org/0000-0001-8025-5166)
- Donald A. Watson (ORCID: https://orcid.org/0000-0003-4864-297X)
- Sina Rezazadeh (ORCID: https://orcid.org/0000-0002-7090-7519)
Institutions
- University of Delaware (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1021/acs.orglett.5c04507
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00