Evaluation of Sex-Stratified Polygenic Risk Scores for Type 2 Diabetes Mellitus and Glycemic Traits in the Framingham Heart Study
These results highlight the need for larger sex-stratified studies and the optimization of sex-stratified risk models for clinical practice.
Authors
- Alicia Huerta‐Chagoya (ORCID: https://orcid.org/0000-0001-6218-3904)
- Philip Schroeder (ORCID: https://orcid.org/0000-0002-9885-7787)
- N. Wang (ORCID: https://orcid.org/0009-0002-2192-5566)
- Josée Dupuis (ORCID: https://orcid.org/0000-0003-2871-3603)
- Ching‐Ti Liu (ORCID: https://orcid.org/0000-0002-0703-0742)
- Ravi Mandla (ORCID: https://orcid.org/0000-0002-0782-0138)
- Yixin Zhang (ORCID: https://orcid.org/0009-0001-6907-3510)
- Josep M. Mercader (ORCID: https://orcid.org/0000-0001-8494-3660)
- James B. Meigs
Institutions
- Broad Institute (US)
- Boston University (US)
- Harvard University (US)
- Foundation Center (US)
- Massachusetts General Hospital (US)
- Novo Nordisk (United States) (US)
- McGill University (CA)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-12-09
- DOI
- https://doi.org/10.4093/dmj.2025.0557
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Diabetes Association
- Novo Nordisk
- Novo Nordisk Fonden
- National Institutes of Health
- National Human Genome Research Institute
- National Institute of Diabetes and Digestive and Kidney Diseases