Urinary betaine/creatinine ratio enhances diagnostic accuracy of PLA2R-Ab in idiopathic membranous nephropathy
Urinary metabolomics uncovered characteristic metabolic disturbances in IMN, involving pathways related to podocyte injury and osmotic regulation. The betaine/uCr showed preliminary potential as an auxiliary diagnostic marker when combined with PLA2R-Ab, though its specificity required further investigation. Therefore, broader studies are needed to establish its clinical utility.
Authors
- Baoxu Lin (ORCID: https://orcid.org/0000-0001-9313-2237)
- Xiaosong Qin
- Ying Xi
- Jin Wang (ORCID: https://orcid.org/0000-0002-7957-5282)
- Yangyang Jiang (ORCID: https://orcid.org/0000-0001-8291-4161)
- Shao Long
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12882-025-04650-x
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00