OPG-Producing B Cells and RANKL-Expressing T Cells Define Immune Signatures Predictive of Bone Metastases in Breast Cancer
This study identifies opposing RANKL+ T cell and OPG-producing B cell immune phenotypes that shape bone metastasis risk in breast cancer. By revealing how these adaptive lymphocyte subsets influence osteolysis and skeletal colonization, our findings define prognostic immune signatures with potential utility for early risk stratification and clinical decision-making.
Authors
- Bárbara Du Rocher (ORCID: https://orcid.org/0000-0002-1020-8038)
- Liebert Parreiras Nogueira (ORCID: https://orcid.org/0000-0002-7767-464X)
- Cecília Vianna de Andrade (ORCID: https://orcid.org/0000-0001-7980-4367)
- Ana Carolina Monteiro (ORCID: https://orcid.org/0000-0001-7899-6264)
- Adriana Bonomo (ORCID: https://orcid.org/0000-0002-3938-9514)
- Ana Paula Gregório Alves Fontão (ORCID: https://orcid.org/0000-0001-5969-1115)
- Marcos V. Colaço (ORCID: https://orcid.org/0000-0002-0174-3063)
- Maria de Fátima Dias Gauí (ORCID: https://orcid.org/0000-0003-3053-839X)
- Lucas Gonçalves Carvalho (ORCID: https://orcid.org/0009-0003-1025-9630)
- Michel Masset (ORCID: https://orcid.org/0000-0003-0974-5079)
- Gabriel Fidalgo (ORCID: https://orcid.org/0000-0003-4739-7052)
- Diego de Andrade Garcia (ORCID: https://orcid.org/0009-0000-7124-7762)
- Izabella Bandeira Alves (ORCID: https://orcid.org/0009-0006-0392-4155)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal Fluminense (BR)
- University of Oslo (NO)
- Brazilian Academy of Sciences (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- International Neuromodulation Society (US)
- Fundação Oswaldo Cruz (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0696
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico