Blockade of Interleukin-6 Trans-signaling in the Presence of Certain Gut Microbiota Induces Mature-onset Obesity in Mice

These findings reveal the crucial functions of IL-6 trans-signaling in preventing mature-onset body fat accumulation induced by certain intestinal microbiota.

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Publication Details

Journal
Gastro Hep Advances
Published
2025-10-01
DOI
https://doi.org/10.1016/j.gastha.2025.100819
Primary Topic
Adipokines, Inflammation, and Metabolic Diseases
Type
article
Field-Weighted Citation Impact
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article

Blockade of Interleukin-6 Trans-signaling in the Presence of Certain Gut Microbiota Induces Mature-onset Obesity in Mice

Shiran Udi, Dirk Schmidt‐Arras, Sharona Elgavish, Dana Eidelshtein et al.
Gastro Hep Advances
Adipokines, Inflammation, and Metabolic Diseases
article

Blockade of Interleukin-6 Trans-signaling in the Presence of Certain Gut Microbiota Induces Mature-onset Obesity in Mice

Shiran Udi, Dirk Schmidt‐Arras, Sharona Elgavish, Dana Eidelshtein, Jonathan H. Axelrod, Hadar Benyamini, Uria Mor, Saja Baraghithy, Ateequr Rehman, Philip Rosenstiel, Anastasios D. Giannou, Joseph Tam, S Perles, Shmuel Ruppo, Jacob Rachmilewitz, Eran Elinav, Rinat Abramovitch, Tali Lanton, Stefan Rose‐John, Evan G. Williams, Eithan Galun, Samuel Huber, Orit Pappo
article en

Abstract

These findings reveal the crucial functions of IL-6 trans-signaling in preventing mature-onset body fat accumulation induced by certain intestinal microbiota.

Gastro Hep AdvancesVol. 5(2)
Universität Hamburg (DE), University of Luxembourg (LU), Hebrew University of Jerusalem (IL), Heidelberg University (DE), Hadassah Medical Center (IL), Christian-Albrechts-Universität zu Kiel (DE), University Medical Center Hamburg-Eppendorf (DE), Israeli Centers for Research Excellence (IL), DKFZ-ZMBH Alliance (DE), Weizmann Institute of Science (IL)
Openalex Percentile: Top 49%
Adipokines, Inflammation, and Metabolic Diseases
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