Blockade of Interleukin-6 Trans-signaling in the Presence of Certain Gut Microbiota Induces Mature-onset Obesity in Mice
These findings reveal the crucial functions of IL-6 trans-signaling in preventing mature-onset body fat accumulation induced by certain intestinal microbiota.
Authors
- Shiran Udi
- Dirk Schmidt‐Arras (ORCID: https://orcid.org/0000-0002-1072-7495)
- Sharona Elgavish (ORCID: https://orcid.org/0000-0001-8418-7412)
- Dana Eidelshtein
- Jonathan H. Axelrod (ORCID: https://orcid.org/0000-0002-8996-3916)
- Hadar Benyamini
- Uria Mor (ORCID: https://orcid.org/0000-0002-2918-6406)
- Saja Baraghithy (ORCID: https://orcid.org/0000-0003-1526-7173)
- Ateequr Rehman (ORCID: https://orcid.org/0000-0002-5664-4628)
- Philip Rosenstiel (ORCID: https://orcid.org/0000-0002-9692-8828)
- Anastasios D. Giannou (ORCID: https://orcid.org/0000-0002-4152-4201)
- Joseph Tam (ORCID: https://orcid.org/0000-0002-0948-0093)
- S Perles (ORCID: https://orcid.org/0000-0001-8758-8756)
- Shmuel Ruppo (ORCID: https://orcid.org/0000-0001-9405-0049)
- Jacob Rachmilewitz (ORCID: https://orcid.org/0000-0002-6662-7987)
- Eran Elinav (ORCID: https://orcid.org/0000-0002-5775-2110)
- Rinat Abramovitch (ORCID: https://orcid.org/0000-0003-1126-7467)
- Tali Lanton
- Stefan Rose‐John (ORCID: https://orcid.org/0000-0002-7519-3279)
- Evan G. Williams (ORCID: https://orcid.org/0000-0002-9746-376X)
- Eithan Galun (ORCID: https://orcid.org/0000-0002-6243-6702)
- Samuel Huber (ORCID: https://orcid.org/0000-0001-9325-8227)
- Orit Pappo
Institutions
- Universität Hamburg (DE)
- University of Luxembourg (LU)
- Hebrew University of Jerusalem (IL)
- Heidelberg University (DE)
- Hadassah Medical Center (IL)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Israeli Centers for Research Excellence (IL)
- DKFZ-ZMBH Alliance (DE)
- Weizmann Institute of Science (IL)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.gastha.2025.100819
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00