Peptide-based aggregation-induced emission fluorescent probe for rapid and accurate detection of low molecular weight heparin
Monitoring low molecular weight heparin (LMWH) is essential in clinical practice. We present a peptide-based aggregation-induced emission fluorescent probe, Z-BTDPA-Pep, capable of rapid, sensitive, and selective detection of LMWH in serum (0.1-2.0 U ml<sup>-1</sup>, LOD = 0.00378 U ml<sup>-1</sup>). The results correlate well with the clinical gold-standard anti-Xa assay, highlighting its potential for real-time LMWH monitoring and safer clinical drug administration.
Authors
- Jia Ju
- Kai Zeng (ORCID: https://orcid.org/0000-0002-2745-1253)
- Fan Fang (ORCID: https://orcid.org/0000-0002-1208-1528)
- Jieman Lin
- Meiyu Lin (ORCID: https://orcid.org/0000-0002-2463-7642)
- Xiaofei Chen (ORCID: https://orcid.org/0009-0002-2148-1416)
- Wenyu Liu (ORCID: https://orcid.org/0000-0001-5025-5376)
- Tianhua Li (ORCID: https://orcid.org/0000-0003-3906-4602)
- Yingying Zhu (ORCID: https://orcid.org/0000-0003-3920-5890)
Institutions
- University of Shanghai for Science and Technology (CN)
- Second Military Medical University (CN)
- People 's Liberation Army 451 Hospital (CN)
- Air Force Engineering University (CN)
- Chengdu Military General Hospital (CN)
- Xi'an Medical University (CN)
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1039/d5cc05295e
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00