Impact of combined hormonal contraceptives and metformin on metabolic syndrome in women with hyperandrogenic polycystic ovary syndrome and obesity: The COMET-PCOS randomized clinical trial

Authors

Anuja Dokras (ORCID: https://orcid.org/0000-0002-1085-3969)
Nehal N. Mehta (ORCID: https://orcid.org/0000-0003-4939-5130)
Richard S. Legro (ORCID: https://orcid.org/0000-0001-9927-7584)
Allen R. Kunselman (ORCID: https://orcid.org/0000-0001-8485-2953)
C. Stetter
Christos Coutifaris
Martin P. Playford (ORCID: https://orcid.org/0000-0002-5571-7266)
William C. Dodson
Alan T. Remaley

Institutions

Hershey (United States) (US)
George Washington University (US)
National Heart, Lung, and Blood Institute (US)
University of Pennsylvania (US)
Penn State Milton S. Hershey Medical Center (US)

Publication Details

Journal: PLoS Medicine
Published: 2025-12-08
DOI: https://doi.org/10.1371/journal.pmed.1004662
Primary Topic: Ovarian function and disorders
Type: article
Field-Weighted Citation Impact: 0.00

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article

Impact of combined hormonal contraceptives and metformin on metabolic syndrome in women with hyperandrogenic polycystic ovary syndrome and obesity: The COMET-PCOS randomized clinical trial

Anuja Dokras, Nehal N. Mehta, Richard S. Legro, Allen R. Kunselman et al.

Dec 8, 2025

PLoS Medicine

Ovarian function and disorders

article

Impact of combined hormonal contraceptives and metformin on metabolic syndrome in women with hyperandrogenic polycystic ovary syndrome and obesity: The COMET-PCOS randomized clinical trial

Anuja Dokras, Nehal N. Mehta, Richard S. Legro, Allen R. Kunselman, C. Stetter, Christos Coutifaris, Martin P. Playford, William C. Dodson, Alan T. Remaley

December 8, 2025article en

Abstract

No abstract available for this paper.

PLoS MedicineVol. 22(12)

Hershey (United States) (US), George Washington University (US), National Heart, Lung, and Blood Institute (US), University of Pennsylvania (US), Penn State Milton S. Hershey Medical Center (US)

Openalex Percentile: Top 49%

Ovarian function and disorders

DOI Open Access PDF OpenAlex

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