A multiple signal-amplified electrochemiluminescence biosensor for ultrasensitive detection of bladder cancer-associated circRNA in urine
An ultrasensitive electrochemiluminescence (ECL) biosensor was constructed for circular RNA detection by integrating an Fe-based metal-organic framework functionalized with gold nanoparticles (Fe-MOF@AuNPs) with rolling circle amplification (RCA) and cyclic amplification. The platform demonstrated excellent performance in urine samples, highlighting its potential for non-invasive early clinical diagnostics and biomedical research.
Authors
- Xiaoman Ju (ORCID: https://orcid.org/0000-0001-8399-516X)
- Jie Chao (ORCID: https://orcid.org/0000-0003-1030-9944)
- Hao Lin (ORCID: https://orcid.org/0000-0001-6265-2862)
- Jingjing Zhang (ORCID: https://orcid.org/0009-0007-8591-5515)
- Ziqiang Wang (ORCID: https://orcid.org/0000-0002-0410-2640)
Institutions
- Nanjing University of Posts and Telecommunications (CN)
- Xuzhou Central Hospital (CN)
- Karamay Central Hospital of Xinjiang (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1039/d5cc05842b
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00