Efficacy based on dose-response and safety of bone marrow-derived mesenchymal stem cells for the treatment of osteoarthritis: a systematic review and meta-analysis
Based on the findings of this meta-analysis, BM-MSCs, especially in the long term, can be effective in reducing pain, stiffness, and improving the quality of life of patients with osteoarthritis. Also, the favorable safety of these cells makes them a promising option in joint reconstruction treatments. However, due to the heterogeneity of studies and the lack of standardized information on the optimal dose, it seems necessary to conduct prospective studies with careful design and long-term follow-up.
Authors
- Vahideh Toopchizadeh (ORCID: https://orcid.org/0000-0002-8177-1127)
- Hadi Hamedfar (ORCID: https://orcid.org/0000-0003-1590-9965)
- Samira Pourzeinali (ORCID: https://orcid.org/0000-0002-8047-5887)
- Soraya Babaie (ORCID: https://orcid.org/0000-0003-0259-2866)
- Azizeh Farshbaf‐Khalili (ORCID: https://orcid.org/0000-0001-5754-4613)
- Elnaz Lohrasbi (ORCID: https://orcid.org/0009-0005-5375-3406)
Institutions
- Tabriz University of Medical Sciences (IR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s13287-025-04799-0
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tabriz University of Medical Sciences
- University of Tabriz