Bovine viral diarrhea virus suppresses type I IFN production by inducing MAVS degradation via autophagy mediated by the ROS-endoplasmic reticulum stress axis

Bovine viral diarrhea virus (BVDV), the causative agent of bovine viral diarrhea-mucosal disease, is a major global threat to cattle health. BVDV employs sophisticated strategies to evade host defense and facilitate its replication. Understanding these mechanisms is crucial for developing effective vaccines and antiviral agents. Our study elucidates how cytopathic BVDV and non-cytopathic BVDV subvert the host's antiviral innate immune response by exploiting autophagy to inhibit the RIG-I-MAVS pathway. A key finding is that BECN1-mediated autophagy directly targets MAVS protein for degradation via a specific BECN1 and MAVS interaction. Furthermore, we demonstrate that BVDV activates autophagy through ROS-ER stress axis to promote its replication. These insights reveal a novel immune evasion mechanism of BVDV and highlight the therapeutic potential of autophagy inhibition in treating BVDV-related diseases.

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Publication Details

Journal
Journal of Virology
Published
2025-12-09
DOI
https://doi.org/10.1128/jvi.01643-25
Primary Topic
Animal Disease Management and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Bovine viral diarrhea virus suppresses type I IFN production by inducing MAVS degradation via autophagy mediated by the ROS-endoplasmic reticulum stress axis

Jiayi Xiang, Yimei Liu, Jiacun Liu, Xinyue Xia et al.
Journal of Virology
Animal Disease Management and Epidemiology
article

Bovine viral diarrhea virus suppresses type I IFN production by inducing MAVS degradation via autophagy mediated by the ROS-endoplasmic reticulum stress axis

Jiayi Xiang, Yimei Liu, Jiacun Liu, Xinyue Xia, Shuo Jia, Yigang Xu, Wenlu Fan, Jiangfei Zhou, Haolin Zhu, Yixin Wang, Qi Wang, Xiao Li, Jing Wang, Jiarui Chen, Renjie Xu, Han Yu, Yuan Li, M. Mao
article en

Abstract

Bovine viral diarrhea virus (BVDV), the causative agent of bovine viral diarrhea-mucosal disease, is a major global threat to cattle health. BVDV employs sophisticated strategies to evade host defense and facilitate its replication. Understanding these mechanisms is crucial for developing effective vaccines and antiviral agents. Our study elucidates how cytopathic BVDV and non-cytopathic BVDV subvert the host's antiviral innate immune response by exploiting autophagy to inhibit the RIG-I-MAVS pathway. A key finding is that BECN1-mediated autophagy directly targets MAVS protein for degradation via a specific BECN1 and MAVS interaction. Furthermore, we demonstrate that BVDV activates autophagy through ROS-ER stress axis to promote its replication. These insights reveal a novel immune evasion mechanism of BVDV and highlight the therapeutic potential of autophagy inhibition in treating BVDV-related diseases.

Journal of VirologyVol. 100(1)
Zhejiang A & F University (CN), Shanghai Medical College of Fudan University (CN), Northeast Agricultural University (CN), Fudan University (CN), Ministry of Education (KN), Zhongkai University of Agriculture and Engineering (CN)
Openalex Percentile: Top 51%
Animal Disease Management and Epidemiology
DOIOpen Access PDFOpenAlex
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