Intensification with a CCR5 inhibitor at antiretroviral therapy initiation modulates interleukin-18 and inflammation-driven immune pathways in people with HIV
Our results suggest that MVC intensification at ART initiation might contribute to reducing interleukin-18 levels and inflammation-driven immune pathways, providing insights for strategies to mitigate persistent inflammation in PWH.
Authors
- Andrés Ruiz-Sancho (ORCID: https://orcid.org/0000-0002-7646-2135)
- Juan Macı́as (ORCID: https://orcid.org/0000-0002-4778-790X)
- Alfonso Muriel (ORCID: https://orcid.org/0000-0002-4805-4011)
- Antonio Rivero (ORCID: https://orcid.org/0000-0002-8643-4250)
- Erick De La Torre Tarazona (ORCID: https://orcid.org/0000-0003-0325-3735)
- Julián Olalla (ORCID: https://orcid.org/0000-0002-8577-3891)
- Sergio Serrano‐Villar (ORCID: https://orcid.org/0000-0002-5447-3554)
- José Alcamı́ (ORCID: https://orcid.org/0000-0003-0023-7377)
- Marta Rava (ORCID: https://orcid.org/0000-0003-2260-9370)
- Santiago Moreno (ORCID: https://orcid.org/0000-0002-2843-1094)
- Diana Patricia Morales Díaz
- Begoña Alcaraz Vidal
- María Fons-Contreras
- Sergio Calderón-Vicente (ORCID: https://orcid.org/0000-0003-1328-2847)
Institutions
- Instituto Cajal (ES)
- Hospital Universitario de Canarias (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Costa del Sol (ES)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Santa Lucía University General Hospital (ES)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1016/j.ijid.2025.108306
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00