Eriocitrin inhibits sodium iodate-induced cuproptosis and barrier function impairment in retinal pigment epithelium via SIRT7/YAP/ATP7A pathway
This study demonstrated that eriocitrin alleviates NaIO₃-induced oxidative stress and RPE barrier dysfunction by modulating the SIRT7/YAP/ATP7A signaling pathway and inhibiting cuproptosis. Our findings indicated eriocitrin as a promising natural therapeutic candidate for dry AMD and lay the foundation for developing flavonoid-based anti-cuproptosis strategies.
Authors
- Heting Liu (ORCID: https://orcid.org/0009-0002-3006-7225)
- Jie Gao (ORCID: https://orcid.org/0000-0001-6680-4288)
- Siyu Gui
- Yumei Tao
- Xiaoyan Liu (ORCID: https://orcid.org/0000-0002-6448-2008)
- Xinchen Wang (ORCID: https://orcid.org/0000-0002-6169-665X)
Institutions
- Shanghai Jiao Tong University (CN)
- Anhui Medical University (CN)
- Shanghai First People's Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12967-025-07451-w
- Primary Topic
- Saffron Plant Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00