Australian Real‐World Effectiveness and Safety of Ustekinumab for the Treatment of Crohn's Disease: Results of the <scp>AURORA</scp> Study, Including the <scp>ANZIBD</scp> Consortium
This real-world study on the use of ustekinumab in Crohn's disease showed that short-term clinical response and remission rates are higher in bio-naïve compared with bio-exposed patients, with a high persistence rate at 15 months. The addition of an immunomodulator did not significantly impact outcomes. Ustekinumab was found to be safe in most patients.
Authors
- Robert Venning Bryant (ORCID: https://orcid.org/0000-0003-4229-3289)
- Hansjoerg Seltenreich
- Niamh Lindsay
- Lauren S. White (ORCID: https://orcid.org/0000-0002-6568-6344)
- Daniel Lightowler (ORCID: https://orcid.org/0009-0005-8424-5594)
- Peter De Cruz (ORCID: https://orcid.org/0000-0002-3399-7236)
- Anna Amiss
- Graham Radford‐Smith (ORCID: https://orcid.org/0000-0002-2047-6239)
- Rupert W. Leong (ORCID: https://orcid.org/0000-0001-5944-3488)
- Britt Christensen (ORCID: https://orcid.org/0000-0002-8746-4275)
- Kavitha Subramaniam (ORCID: https://orcid.org/0000-0002-7828-5398)
- Jane M. Andrews (ORCID: https://orcid.org/0000-0001-7960-2650)
- Simon Ghaly (ORCID: https://orcid.org/0000-0003-2489-6430)
- Lena Thin (ORCID: https://orcid.org/0000-0003-2816-3533)
- Soong‐Yuan Ooi (ORCID: https://orcid.org/0000-0003-1302-5365)
- C Li Wai Suen (ORCID: https://orcid.org/0000-0003-4095-1153)
- Robert Gilmore (ORCID: https://orcid.org/0000-0002-6648-658X)
- Susan J. Connor (ORCID: https://orcid.org/0000-0001-5606-0270)
- Daniel R. Van Langenberg
- Hai D. Pham (ORCID: https://orcid.org/0000-0002-6350-368X)
- Viraj C. Kariyawasam (ORCID: https://orcid.org/0000-0003-2623-1336)
- Nikola Mitrev (ORCID: https://orcid.org/0000-0001-7771-5248)
- Jakob Begun (ORCID: https://orcid.org/0000-0001-5256-7672)
- Nik S. Ding (ORCID: https://orcid.org/0000-0002-6232-1948)
- Yoon‐Kyo An (ORCID: https://orcid.org/0000-0002-1458-8015)
- Richard Fernandes (ORCID: https://orcid.org/0000-0002-9123-0228)
- Emi Khoo (ORCID: https://orcid.org/0000-0003-3536-4974)
- Miles Sparrow (ORCID: https://orcid.org/0000-0003-2527-8044)
- Natalie Allan
- Astrid Williams
Institutions
- Australian National University (AU)
- The University of Sydney (AU)
- Royal Adelaide Hospital (AU)
- The Royal Melbourne Hospital (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- University of the Sunshine Coast (AU)
- The University of Western Australia (AU)
- QIMR Berghofer Medical Research Institute (AU)
- Royal Brisbane and Women's Hospital (AU)
- Concord Repatriation General Hospital (AU)
- Austin Hospital (AU)
- Fiona Stanley Hospital (AU)
- Liverpool Hospital (AU)
- Blacktown & Mount Druitt Hospital (AU)
- Canberra Hospital (AU)
- UNSW Sydney (AU)
- St Vincent's Hospital Melbourne (AU)
- St Vincent's Hospital Sydney (AU)
- Mater Research (AU)
- Monash Alfred Psychiatry Research centre (AU)
- Eastern Health (AU)
- Queen Elizabeth Hospital (AU)
- Sunshine Coast University Hospital (AU)
- Monash Health (AU)
- Mater Adult Hospital (AU)
- Alfred Health (AU)
- ACT Government (AU)
- Monash University (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- JGH Open
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jgh3.70322
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cilag