Ultrasonic-assisted, additive-free Pd-catalyzed Suzuki–Miyaura cross-coupling enabled synthesis of novel arylated benzofuran-triazole hybrids
An additive-free and ultrasound-assisted approach has been established for the Suzuki-Miyaura cross-coupling reaction between substituted boronic acid and benzofuran-endowed aryl halides by employing a catalytic amount of Pd(PPh<sub>3</sub>)<sub>4</sub>. The resulting substituted biaryls were then employed as efficient starting materials to furnish a novel library of arylated benzofuran-triazole hybrids <b>13(a-i)</b>. The method offers a facile, efficient, and less time-consuming approach under non-inert conditions to synthesize the targeted derivatives in a good to excellent yield range of 70%-92%.
Authors
- Mariusz Mojzych (ORCID: https://orcid.org/0000-0002-9884-6068)
- Ali Irfan (ORCID: https://orcid.org/0000-0002-8977-3303)
- Sajjad Ahmad (ORCID: https://orcid.org/0000-0002-1139-8726)
- Saba Munawar (ORCID: https://orcid.org/0000-0001-6934-5857)
- Katarzyna Kotwica-Mojzych (ORCID: https://orcid.org/0000-0002-3655-7324)
- Muhammad Jawwad Saif (ORCID: https://orcid.org/0000-0002-9589-876X)
- Ameer Fawad Zahoor (ORCID: https://orcid.org/0000-0003-2127-8848)
- Aqsa Mushtaq
- Karol Ruszel
- Shoela Ettampola
Institutions
- Medical University of Lublin (PL)
- University of Engineering and Technology Lahore (PK)
- Government College University, Faisalabad (PK)
- Dunwoody College of Technology (US)
- University of Faisalabad (PK)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fchem.2025.1726528
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uniwersytet Medyczny w Lublinie