Circulating C-terminal peptides and polymers of alpha-1 antitrypsin as putative markers of pediatric Pi*ZZ liver disease
Peptides C37 and C42 emerge as promising AAT-derived markers of hepatocellular status in stable Pi*ZZ children, while AAT polymers appear to reflect distinct features of cholestatic or hepatocellular stress. Together, these markers may support early risk stratification and therapeutic monitoring in pediatric AATD-related liver disease. Validation in larger, longitudinal cohorts is warranted to confirm their clinical utility.
Authors
- David Katzer (ORCID: https://orcid.org/0000-0002-7562-5940)
- Sabina Janciauskiene (ORCID: https://orcid.org/0000-0001-7687-5258)
- Rainer Ganschow (ORCID: https://orcid.org/0000-0002-5915-8633)
- Alexander Weigert
- P Mielczarek
- Michael Kiehntopf
- Julia Held (ORCID: https://orcid.org/0009-0002-6730-9128)
- Soyhan Bağcı (ORCID: https://orcid.org/0000-0003-1005-665X)
- Friedemann Börner
- Alexander Machui
Institutions
- University Hospital Bonn (DE)
- Medizinische Hochschule Hannover (DE)
- Zimmer Biomet (Germany) (DE)
- Jena University Hospital (DE)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fped.2025.1717317
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00