Physiological stage-dependent effects of Mycobacterium tuberculosis on human placental tissue: insights into early reactivation and immune modulation
Mtb can infect, persist, and replicate within human placental tissue, compromising its structural and immune integrity. These effects vary with the bacterial physiological phase, with early-reactivated Mtb showing the greatest capacity for tissue dissemination and damage. These findings underscore a dual risk of placental injury and increased potential for vertical transmission during early reactivation, emphasizing the need for timely TB screening and intervention during pregnancy.
Authors
- Sandra Rivera-Gutiérrez (ORCID: https://orcid.org/0000-0003-1556-9956)
- Oscar Villavicencio‐Carrisoza (ORCID: https://orcid.org/0000-0002-7091-8840)
- Arturo Flores‐Pliego (ORCID: https://orcid.org/0000-0001-7876-6098)
- Diana A. Aguilar-Ayala (ORCID: https://orcid.org/0000-0001-5280-4260)
- Addy Cecilia Helguera‐Repetto (ORCID: https://orcid.org/0000-0001-6715-9671)
- Maria Isabel Villegas-Mota (ORCID: https://orcid.org/0000-0001-6678-1282)
- Jorge Francisco Cerna-Cortés (ORCID: https://orcid.org/0000-0002-4350-9507)
- Aurora Espejel-Núñez (ORCID: https://orcid.org/0000-0001-9087-8017)
- Andrea Olmos‐Ortiz (ORCID: https://orcid.org/0000-0002-5456-9695)
- María Yolotzín Valdespino-Vázquez (ORCID: https://orcid.org/0000-0003-4735-4730)
- Verónica Zaga‐Clavellina (ORCID: https://orcid.org/0000-0002-3365-2932)
- Orly Grobeisen-Duque (ORCID: https://orcid.org/0000-0001-6541-5934)
- Mónica Selena Fonseca-Pérez
- Luis Antonio Herrera-Moro-Huitron
- Belen Betsaida del-Castillo-Hernandez
- Jose Ramon Rojo-Garcia
Institutions
- University of Quintana Roo (MX)
- John Radcliffe Hospital (GB)
- Instituto Nacional de Perinatología (MX)
- Secretaria de Salud (MX)
- Instituto Tecnológico de Chetumal (MX)
- Secretaria de Salud (HN)
- Instituto Politécnico Nacional (MX)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-12-10
- DOI
- https://doi.org/10.3389/fmicb.2025.1682405
- Primary Topic
- Diagnosis and treatment of tuberculosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto Nacional de Perinatología